The main objective of the present investigation was to study comparative evaluation of nimesulide tablet formulation by using different superdisintegrants. In this comparative study were developed two types of superdisintegrant one is the natural like maize starch and potato starch another is the synthetic superdisnterant like sodium starch glycolate and microcrystalline cellulose. The tablets of the nimesulide were prepared by direct compression technique. The prepared tablets evaluated in terms of their pre-compression studies, post-compression studies and in vitro study and release kinectic study. The Disitegration study and Invitro study showed that formulation of natural superdisintegrant gives better result than the synthetic superdisintegrants.

The Amravati region displays diversity in Flora. Pollen grains present in the honey represents the plant diversity of the foraging area of honeybees. For aging activity of honey includes nectar along with the pollen grains. Keeping such perspectives investigation is made for assessment of pollen diversity in six different sampling sites from Amravati region. Color and texture of honey is also depends on the foraging site of honeybees. Out of six sampling sites Pohara showed the highest i.e. thirteen different pollen types in the collected honey and least variation in pollen diversity of honey was recorded from Tapovan site i.e. four. Sculpturing pattern and ornamentation of exine in pollen is very specific to particular plant species. Such morphological features of pollen were utilized for identification of pollen grains.

Siddha system of Medicine, one among the ancient traditional medical system of India that has been practiced for 2000 years and above. Siddha system of medicine is a vast repository of internal and external medicines. These procedures are as important as the internal medicines in the management of health and disease. According to the mode of application, the Siddha medicines could be categorized into two classes: Aga marunthugal/Internal medicine were used through the oral route and further classified into 32 categories based on their form, methods of preparation, shelf - life, etc. Pura marunthugal/External medicine includes certain forms of drugs and also certain applications (such as nasal, eye and ear drops), and also certain procedures (such as leech application). It is also classified into 32 categories. External therapy procedures are as important as in the management of Health and Disease. In several instances only the External therapy without any drug is sufficient and these procedures are already systematized. Most of these therapies are aimed at maintaining a healthy balance of three humours Vatham, Pitham and Kabam and also the seven tissue types of the body. Hence, an attempt was made to recollect information regarding External therapies in Siddha System of medicine.

Siddha system of Medicine is a complete Holistic traditional medicine practiced all over Tamil Nadu since ancient days. Ancient Siddha Literatures mentioned the diseases as 4448. Sage Yugi has described 80 types of vatha diseases, Arputhavatham is one among the 80 types of vatha diseases mentioned by Sage Yugi in his text Yugi vaithya chindhamani. This vatha disease can be correlated with Facial tics in modern disease of classification. A facial tic is a repeated spasm, often involving the eyes and muscles of the face. The disorder occurs worldwide and affects about 0.1% to 1.0% of individuals in the general population. TICS occur more frequently in males than in females: a ratio of about 2 or 4 to 1. According to Brunn (1988) the onset is with facial tics in 66%, and with phonatory tic in 13% of cases. Tics rarely begin before the age of three years, usually manifesting between 5 to 15 years of age. By relating Ancient Siddha literatures with today there will be augmentation of knowledge of diagnosis and its treatment. This is an attempt to unravell the mystery that lies in the condition “Arputha vatham” one of the 85 types of Vaatha diseases which was propounded by Sage Yugi. This paper also parallely analyses the clinical correlation between Arputha vatham and Facial tics.

The pasture of nanochemistry research has shown an immense development in the embryonic of novel nanocarriers as prospective drug delivery systems. Niosome is used as a colloidal vesicular carrier in drug delivery and is a class of molecular cluster formed by self-association of non-ionic surfactants in an aqueous phase. The unique structure of niosome presents an effective novel drug delivery system (NDDS) with ability of loading both hydrophilic and lipophillic drugs. Development trends in nanotechnology in health and medicine are expected to provide solution to many of modern medicines unsolved problems. Nanotechnology offers potential developments in therapeutics, diagnosis, cancer treatment, implantable materials, and tissue regeneration and made up of non-ionic surfactant vesicles which are biodegradable and safe. These are cost effective and stable compared with other colloid carriers. It has applications in oral, topical, parental and novel drug delivery as controlled and targeted delivery. This review article focuses on niosome structure, composition, advantages, types of niosomes, methods of preparation, characterization and its application.