Solid oral dosage forms are most convenient from patient as well as from manufacturing chemist's perspective. Dispersible tablets are required to disintegrate within 3 mins in water at 15-25°C. Also the dispersion produced from a dispersible tablet should pass through a sieve screen with a nominal mesh aperture of 710 microns. The objective of present study is to design and develop a stable solid oral dosage form of Deferasirox dispersible tablets by using Croscarmellose Sodium and MCC PH101 to deliver with optimum concentration of drug at desired site at specific time comparable to the innovator product with better stability, high production feasibility, and excellent patient compatibility. 

Ofloxacin acts intracellularly by inhibiting DNA gyrase. DNA gyrase is an essential bacterial enzyme that is a critical catalyst in the replication, transcription, deactivation, and repair of bacterial DNA.In this study Floating tablets of Ofloxacin was formulated with HPMC to retain the tablet dosage form in the stomach and to release the drug in a controlled manner for increasing the oral bioavailability of the Ofloxacin. In the present work direct compression method were used to prepare floating matrix tablets of Ofloxacin. The tablets were found to be floating immediately upon contact with the release medium showing no lag times in floating behaviourbecause of the low density material. Extended floating times are achieved due to the air entrapped within the drug particles.

Tablets may be defined as solid unit pharmaceutical dosage forms containing drug substance with or without suitable excipients and prepared by either compression or molding methods. Zolmitriptan is a selective agonist of serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1Dreceptors.In this study immediate release monolithic tablets of Zolmitriptan using sublimation technique. Immediate release tablets of Zolmitriptan were prepared by the direct compression technique using subliming agents like camphor and Crospovidone as superdisintegrant are used. The sublimation technique is mainly used to ensure burst release by forming porous tablet matrix so that it does swell and entrap Zolmitriptan which results in fast absorption of Zolmitriptan. Subliming agents are sublimed from the tablets by drying in hot air oven at 60oC for 12 hrs. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, and in vitro dissolution.

The aim of the present study was to formulate and characterize polysorbate-80 coated PLGA nanoparticles to target brain upon oral administration. Rivastigmine tartrate (RT) loaded PLGA nanoparticles were prepared by adopting modified nanoprecipitation method and were later coated with polysorbate 80 (PS80) and characterized for particle size, morphology physical state, drug entrapment and in vitro release. Further, in vivo pharmacokinetics studies conducted in rat exhibited the AUC_0-24 ofRT in rivastigmine nanoparticle (R-NP) was (4825.9ng/ml) which was higher when compared with the AUC_0-24 of rivastigmine solution R-sol (224.483ng/hr). Tissue distribution studies of RT in brain after oral administration of polysorbate 80 coated nanoparticles (RNP-PS-80) was found to be 60.99ng/ g tissue and 93.5ng/g tissue as compared with the uncoated R-NP 30.0ng/g tissue and 41.33 ng/g tissue at 1^st and 4^th hour respectively. Histopathology of the brain sections treated with R-sol, RNP and RNP-PS-80 indicated no morphological changes and toxicity. The brain to blood ratio of RNP-PS-80 was indicates a greater ability of RNP-PS-80 to reach the brain and can be a promising approach for targeted delivery of RT to brain through oral route for the treatment of Alzheimer’s disease.

Recent researches in the field of life science and drug discovery leads to affirmations regarding the application of nanotechnology in drug development process. There are so many applications of nanotechnology in the diverse fields including physical science; medical science etc. Current study discussed the safe and friendly synthesis of nanoparticle using metal silver. Silver has its own importance in therapies mentioned in Ayurvedas and traditional Indian medicines. Urinary tract infection especially nosocomial infections play a crucial role in national health caused by uropathogens includes fungal and bacterial infections. Study reports the antifungal activity of green synthesized nanoparticles using Carica papaya leaves using traditional microbiological methods. Facts founds in the study, compared with the traditional antifungal drugs which shows that synthesized silver nanoparticles with the extract having more potential antifungal activity.

The nanoparticle is defined as the particulate dispersion (solid particles) within the range of 10 to 1000 nm. Nanocapsules are the capsules in which drug particles are surrounded with thin layer of polymers are called nanocapsules. Drug is encapsulated and dissolution with the polymer matrix by dispersion, matriculation method. Major goals of nanoparticle drug delivery system are to control the release parameter of pharmacological active particle to the specific site of the organs. Circulating particles may be defined as the biodegradable polymeric nanoparticles are coated with the hydrophilic polymer like Polly ethyl glycol (PEG). These are used for potentially absorption of drug store achieve the therapeutic response of the drug. Various polymer are used it may be naturally, synthetic and semi synthetic which provide therapeutic response avoided by its side effect.