A promising technique for delivering medications to the desired spot is pharmaceutical nanotechnology. They are widely used in both illness diagnosis and treatment. A cutting-edge technology called nanosponge allows for the regulated delivery of medication for targeted sites. They are minuscule particles with nanoscale cavities that can encapsulate a wide range of medications. They are beneficial as a result of their improved bioavailability and stability. By cross linking CD (cyclodextrin) with carboxylate, nanosponges can be made (cross-linkers). They come in a variety of forms, including Polyamidoamine NS, Modified NS, CD-based carbamate NS, CD-based carbonate NS, and CD-based ester NS. Both oral and topical preparations use them. For the manufacture of Nanosponges, several techniques have been used, including the melt method, solvent method, and ultrasound-assisted synthesis, among others. Polymers, co-polymer, cross-linkers and bioactive substances are used in the manufacture of nanosponges. Proteins, enzymes, antibodies, and vaccinations can all be effectively transported using nanosponges.

The present study aimed to develop matrix type transdermal drug delivery system for selected anti-hyperglycemic agent of Pioglitazone Hydrochloride. Preliminary studies were done to determine the solubility, pH, partition coefficient and steady state flux and permeability coefficient. The steady state flux and the permeability coefficient values obtained from in vitro diffusion studies across Wistar rat skin suggested the need of penetration enhancers in view to achieve the desired flux so as to maintain the therapeutic concentrations. It shows good permeation for the selected drugs. Different ratio batches of drug loaded films were for each drug using a combination of excipient in different ratios by solvent casting technique. Based on the physicochemical properties and drug diffusion profile of the films, it could be concluded that PVP and PVA in ratio of 1:2 were better suited than the other polymer combinations for the development of transdermal drug delivery systems of Pioglitazone Hydrochloride. Drug-Polymer interaction studies were carried out using FT-IR and DSC techniques. The Pharmacodynamic data indicated that the therapeutic action starts at 1 h and sustains up to 24 h, suggesting that the systems developed could be beneficial in the management of diabetic.

Traditional medicines with therapeutic utility have been used since antiquity and are still contributing a significant role in the primary health-care system. Thus this article focused on the extraction, phytochemical, macro and micro minerals and antioxidant potential of Rullia prostrate ethanol and chloroform flower extract. The phytochemical screening revealed that the plant is a rich source of different secondary metabolites like flavonoids, phenol. Elemental analysis showed the presence macro and micro minerals. Hence the ethanol and chloroform flower extract of Rullia prostrate shows many compounds and may have been used in traditional medicine for prevention of several diseases.