Nanotechnology is the science of matter and material which deals with the particle size ranging from 1-1000nm. The solid lipid nanoparticles are novel submicron colloidal carriers which ranges from 50-1000nm which contains physiological lipid, dispersed in water or aqueous surfactant solution. In the current research, studies were carried out to design and characterize solid lipid nanoparticulate delivery systems to enhance the therapeutic efficacy of Risperidone and minimized adverse effects. Risperidone is used in the treatment of Schizophrenia. Risperidone SLNs were prepared by Solvent Injection Method by the use of different lipids, solvents, polymers and distilled water as aqueous phase. The resultant solid lipid nanoparticles of Risperidone were characterized by drug content, encapsulation efficiency, in-vitro drug release, particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). SEM photographs of formulations F3 revealed that nanoparticles were discrete particles with smooth, rigid surface. The drug content was found to be in the range of 30.22±0.24 to 45.24±0.42 and the encapsulation efficiency in the range of 48.50±0.62 to 77.73±0.54. The % cumulative of the formulation ranged from 19.91% to 96.01%. FT-IR study confirmed the drug-lipid compatibility. Best formulation (F3) showed a maximum drug release of 96% in 9 hrs, particle size of 348.6 nm and zeta potential of - 0.898mV. Risperidone solid lipid nanoparticles were best suited with the glyceryl monostearate as a lipid and acetone was used as a solvent. Structural characterization of SLNs by Fourier transform infrared spectroscopy (FTIR) analysis revealed that, there was no interaction of risperidone with lipid and was well dispersed in the lipid matrix without any crystallization.

This study reports the antioxidant properties of three medicinal plant’s flowers namely Lantana camara (Lcf), Euphorbia milii (Emf) and Ixora coccinea (Icf) from India. Preliminary phytochemical were investigations were on carbohydrates, proteins, alkaloids, flavonoids, saponins, total phenols, steroids and terpenoids. Antioxidant and antibacterial activities from dried materials of these flowers were studied using DPPH and FRAP assays. L. camera flower was ranked the highest inhibition of free radicals (81.25%) followed by I. coccinea flower extract (73.78%) and lowest inhibition of free radicals was observed in E. milii flower extract showed least inhibition of 68% activity and IC50 of 0.696 mg/ml for DPPH for L. camara flowers. The highest FRAP value was reported in Lcf showed 70% inhibition. Similarly, flower extracts of Icf exhibited 67% inhibition of FRAP values, when compared with Emf respectively. The antibacterial activity of all flowers showed an appreciable broad spectrum activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa with MIC value ranges between 6 to 9mm of inhibition respectively. The studied flowers possess considerable antioxidant and antibacterial activities and may contribute to the well-being of individuals who consume them.

The medical cost burden is increasing day by day in India. Government has introduced generic medicine centres throughout India under Pradhan Mantri Bhartiya Jan Aushadhi Pariyojana (PMBJP) scheme for the availability of medicines to people at a cheaper cost. This study was conducted to check the knowledge of pharmacist, students from science and non-science background regarding generic and branded medicines and their willingness to opt generic medications. The results showed all of them have minimum knowledge regarding generic medications and they are willing to opt them only on doctor’s advice and prescription.

Niosome are non-ionic surfactant vesicles got on hydration of manufactured nonionic surfactants, with or without fuse of cholesterol or their lipids. They are vesicular frameworks like liposomes that can be utilized as transporters of amphiphilic and lipophilic medications. Baneful are promising vehicle for sedate conveyance and being non-ionic and Niosomes are biodegradable, biocompatible non- immunogenic and display adaptability in their basic portrayal. Niosomes have been broadly assessed for controlled discharge and focused on conveyance for the treatment of malignancy, viral contaminations what's more, other microbial maladies. Niosomes can ensnare both hydrophilic and lipophilic medications and can delay the dissemination of the ensnared tranquilize in body. Exemplification of medication in vesicular framework can be anticipated to delay the presence of medication in the foundational flow and upgrade entrance into target tissue, maybe lessen poisonousness if specific take-up can be accomplished. This audit article centers around the points of interest, Disadvantages, arrangement strategies, factors influencing, portrayals, in vitro strategies, medicate discharge energy and utilizations of baneful.

Many of the Drugs are having poor water solubility and usually associated with low bioavailability. Among different types of systems Micellear systems are having Excellent property of Enhancing solubility and oral bioavailability. The main aim of the study is to formulate and evaluate the polymeric micelles of lipophilic drug paclitaxel using pluronic F-68 by sonication method. The Drug is having Excellent antineoplastic activity but poor bioavailability and poor aqueous solubility. The prepared micelles were subjected to particle size, zeta potential, morphology, Encapsulation Efficiency, in vitro dissolution studies. The mean particle size was 100nm with PDI of 0.241 and zeta potential of +34mV. FTIR studies confirms that there is no interaction between Drug and Pluronic F-68. DSC studies showed that the drug was properly incorporated in to micelles. In vitro dissolution profiles shows 4 times more than that of pure paclitaxel. It was concluded that prepared polymeric micellar system acted as a better carrier for Paclitaxel and showed increased solubility.