Cosmeceutical is a term which is employed for the combination of cosmetic and pharmaceutical and the field of cosmetic technology is robustly dealing these days with the advancement and research of these cosmeceuticals. Cosmeceuticals are basically cosmetic products only but these also possess a drug like activity. Thus they are termed as cosmeceuticals. They were not recognized in the earlier decades but came into existence when a researcher “Kilgman” coined this term. The utilization and popularity of these products expanded globally, primarily after the year 1996. The present paper is an attempt to enlighten the recent work and advancement which is being carried out on cosmeceuticals and how they are proving themselves to be a promising area of interest in the field of cosmetic technology.
The leaf of Daemia extensa R. Br. Family Mantis is reported to have good medicinal values in traditional system of medicines. In present investigation, the herbal syrup from leaves of Daemia extensa was developed. Formulated herbal syrup then subjected to evaluation of production quality by different methods stated as per official compendia. Such evaluation has unique pose in improvement of new formulations.
Murraya koenigii is a medium sized tree belonging to the family Rutaceae. The major constituents present in the Murraya koenigii leaves treat burns, bruises. Ayurveda is a traditional Indian medicinal system practiced for thousands of years. Natural remedies are more acceptable in the faith that they are safer with less side effects than the synthetic ones. The novel formulations are reported to have remarkable advantages over conventional formulations of plant actives and extracts which include enhancement of solubility, bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability, improved tissue macrophages distribution, sustained delivery and protection from physical and chemical degradation. Our main purpose is to treat/heal wound at faster rate with minimum side effects. Nanosponges alone are difficult to use on local tissues because they diffuse away to other parts of the body very quickly so to overcome the drawback we combined nanosponges with the herbal extract of Murraya Koenigii. According to literature survey it was found that etanolic and aqueous extract shows good wound healing results. Research on curry leaves revealed that they are also effective in fighting bacterial and fungal infections. The leaf extracts from the plant have been comparable to popular main stream antibiotic drugs. During this research work, we prepared ethanolic extract of Murraya Koenigii leaves and prepared nansponges from it for treating burn wound. The nanosponges are prepared by quasi emulsion solvent diffusion method. The prepared nanosponges were evaluated for various In-vitro parameters and the results obtained were satisfactory.
Hsitochemical study was carried out to localize polyphenolic terpenoid aldehydes and fixed oil in healthy seeds, stems, leaves and roots of Gossypium Barbadense L. var. Giza 86. In all examined organs, polyphenolic terpenoid aldehydes and fixed oil were mainly detected inside lysigenous glands. In young Leaves and roots, polyphenolic aldehydes were also observed as fine particles inside the cytoplasm of some parenchymatous cells around glands. Lysigenous terpenoid-containing glands were noticed in all tap root regions except the apical 3 cm. The number of glands increased with increasing distance from the root tip. This may explain why the antimitotic activity of gossypol does not affect the growing tip of the plant.
Farid A. Badria*, Wael E. Houssen, Mona G. Zaghlol, Ahmed F. Halim.
Multi-targets drugs, have occupied significant attention in the former decade, as possible therapeutic keys to diseases of complex disorders as diabetes and drug resistant tumors due to their significant advantages. The old lock and key paradigm, it is no longer appreciated due to the idea of highly specific drug targeting only one target is no longer valid. The concept of Multi-targets Drugs has been proven in significant in the treatment of many disorders including but not limited to; Caner, Alzheimer’s disease, Parkinson’s disease, inflammation, depression and more exceeding the advantages of single-target drug with lower drug interactions and side effects and more expected pharmacokinetics. Of course, this technique is fairly young and much more research and development are needed. In a complex disorder X, two targets are needed to be modulated so the patient have to receive two drugs C1 and C2. By using one drug (C3, Multi-targets agent) that can interact with both targets, side effects can be minimized with better patient compliance.