In the present research work has been carried out in Formulation and Evaluation of Felodipine Sustained Release Tablets various biodegradable polymers. Recent advances in novel drug delivery systems aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is oral sustain release formulation. There are many biodegradable polymer used among these HPMC polymers results of the present study demonstrated that combination of both could be successfully employed for formulating sustained release matrix tablets of Felodipine. The sustained release tablets can be expected to reduce the frequency of administration and decrease the dose dependent side effects associated with repeated administration of conventional Felodipine.

The need for the present study is to encapsulate the drug in the niosomes vesicle. Niosomes are non - ionic surfactant vesicles obtained on hydration with synthetic non - ionic surfactants with or without incorporation of cholesterol or other lipid. Niosomes prolong the circulation of many drugs and alter the distribution of drugs, we aimed at formulating linagliptin in niosomal drug delivery, thereby minimizing the dose and also used to achieve sustained release for a prolonged period of time. Preformulation studies were performed for the drug (linagliptin). Two formulations of F-1and F-2 of Linagliptin niosomes were prepared by modified ether injection techniques. Microscopic examination revealed that the vesicle diameter complies with in the range of 100 to 300nm. The entrapment efficiency of drug in F-2 containing span 60 was found to be 71.62% with showed that span 60 is the more suitable surfactant along with cholesterol for enhancing maximum entrapment for the drug linagliptin. F-2 showed 93.71% of drug release within 20 hours. These results showed that niosomes linagliptin has sustained release up to 20 hours.

Nagarmotha (Cyperus Rotunds) is also called as purple nut sedge or nut grass. And it belongs to the family cyperacea. The plant is widely distributed in India as well as other countries. And mostly used in ayurveda to treat several ailments it is used in several system of medicine for treating variety of diseases such as rheumatoid arthritis, whooping cough, strep throat, ear infection and urinary tract infection, cholera, tuberculosis, pneumonia, hepatitis, anxiety, depression, folliculitis. The numerous study proved the various pharmacological activities like anti-inflammatory, antipyretic, carcinogenic, analgesic, sedative, gastroprotective, anti-diarrhoeal, anti-emetic, tranquilizing, antidiabetic, wound healing, anti-bacterial, anti-convulsant, anti-malarial, anti-oxidant, anti-platelet, lipid lowering, anti-cancer, hepato-protective, anti-allergic activity it is full filled with nutritive value present the review aims to provide information related to chemical constituents with their morphology, pharmacological effect as well as their formulation of Cyperus rotundus.

Nanoparticles is a drug delivery system appropriate for almost all type of administration routes of the drug delivery. Over the years, different type of natural and synthetic polymers has been inspected for the formation of nanoparticles, of which Poly (glycolic acid) (PGA), Poly (lactic acid) (PLA) and their copolymers (PLGA) have been widely investigated as it is biocompatibility and biodegradability. Poly (lactic-co-glycolic acid) (PLGA) is one of the effective biodegradable polymeric nanoparticles (NPs). It is approved by the US FDA to be used in drug delivery systems due to its controlled and sustained- release feature, less toxicity, and biocompatibility with cells and tissue. Targeted nano-drug delivery to the colon is advantageous for colon-specific diseases as nanoparticles gets accumulate in diseased parts that improve the efficacies of therapeutics, and localizes treatments, that reduces systemic toxicity. This article deals with the different approaches of PLGA based nanoparticles, that has been used toward the different types of colon drug delivery system.

Since ancient times, herbal treatments have been utilized to treat skin conditions. Even the great apes, who are our closest living relatives, use herbal remedies for self-medication (Huffman 2001). Regional trade in ethnobotanical treatments led to the development of particular herbs and their uses based on locally accessible plants. Throughout Europe, the Middle East (Ghazanfar 1994), Africa, India (Behl and Srivastava 2002), China, Japan, Australia and the Americas, distinct regional herbal use systems have emerged. The Ayurvedic herbs in India and the herb combinations created as a part of traditional Chinese medicine (TCM) in China are two well-known systems that are still in use (Xu 2004). Herbal remedies grew less popular in Europe and the US as refined extracts and synthetic chemical medications were more readily available. There has been a rise of in recent years. Patients and, to a lesser extent, doctors are becoming more interested in herbal treatments, particularly those for skin conditions. Herbal remedies that have been utilized for millennia throughout Asia, particularly in China and India, are now the subject of scientific research. The regulatory body Commission E in Germany is in charge of regulating herbal products and their suggested applications (Blumenthal et al, 1998). The only way that herbal items are currently regulated in the US is as dietary supplements. Active substances, purity, and concentration are not standardized. Also, there are no rules dictating which herbs can be promoted for particular purposes. This review of herbal remediesincludes both the more popular herbs that have been discovered to be effective in the treatment of dermatological conditions as well as those treatments that have scientific data supporting their clinical usefulness.