Copper oxide nanoparticles are of significant importance in many fields of application especially in the biomedical field. Green biosynthesis of these nanoparticles using fungi had not received the necessary attention from researchers despite their excellent fermentation characteristics. This work was a trial to bridge the gap in this respect. Out of nineteen fungal species isolated from the Egyptian soil, only six species could synthesize these nanoparticles using their culture supernatant and/or biomass. Aspergillus fumigtus was confirmed as good candidate for biosynthesis of copper oxide nanoparticles. It could produce the highest yield of nanoparticles when the preformed mycelium was contacted with 1 mM solution of copper nitrate solution adjusted to pH 6 and incubated in the dark at 30oC for 60 h under submerged conditions. The biosynthesized nanoparticles showed characteristic absorption spectrum with intense peak at 335 nm. The nanoparticles were spherical in shape when examined by high resolution transmitting electron microscope. Copper oxide nanoparticles of A. fumigatus were suggested as good free radical scavengers.

Zolmitriptan is a new serotonergic agonist of the 5-HT1D/1B receptor with anti-migraine property and belongs to the class of the triptans. It is extremely bitter in taste. The purpose of this research was to develop a bitterless orally disintegrating tablet of poorly soluble drug like zolmitriptan. Taste masking was done by complexing Kyron T-134 in different ratios. Three super disintegrants like Sodium starch glycolate, Crospovidone, Low substituted hydroxypropyl cellulose were used. Prepared tablets were evaluated for different properties like Drug content, hardness, friability, wetting time, water absorption ratio, disintegration time and In-vitro dissolution studies. The different formulations showed disintegration time between 39 to 52 seconds. Drug release showed between the range of 5 to 30 minutes. Among all the formulations, F9 with Low substituted hydroxypropyl cellulose at a concentration of 4% showed 98.09% drug release within 30 minutes. Thus F9 was considered as best among the other formulations. The tablets showed enhanced dissolution hence better patient compliance. Kinetic analysis (r2) of release data based on best curve-fitting method for selected ODT of Zolmitriptan showed first order kinetics indicating that the drug release depends upon its concentration.

According to gift ways of regenerative medication, It's focus on altered skin (such as burnt skin) which might be transplanted with combination of scaffold and bio molecules. In current years, biologically active scaffolds are being employed as extracellular matrix that may induce synthesis of tissues and organs. Scaffold is needed for the restoration of the perform of tissue and its regeneration because it acts as short term matrix for cell proliferation and extracellular matrix deposition. Scaffolds are used for tissue engineering like bone, cartilage, ligament, skin, vascular tissues, neural tissues, and muscle and as vehicle for the controlled delivery of medicine, proteins, and DNA covering finds its application in a very broad vary of areas as well as artificial intelligence, human-computer interfaces and different areas that involve mechanical deformation. In this paper, an summary of the anatomy of skin, forms of burns, covering scaffolds, its material properties that are used for treating burnt scars and its application is mentioned.

Emulsion is a biphasic liquid dosage form. These are of two type oil in water and water in oil, it is a conventional method now days novel dosage forms are used like microemulsion and nanoemulsion. These are prepared by using different process and provide better bioavilability and response. There size are also differ and provide good result as comparison of emulsion. Novel drug delivery system is commonly used having better approach towards other dosage form. Emulsion is one of the most important system of dosage form. Applications of emulsions increased especially after micro and nano-emulsion emergence. This paper is an attempt to summarise comparative aspects like definition, theories, types, methods of prepara¬tions, advantages, disadvantages and methods of analysis of emulsion, micro-emulsion and nano-emulsion.

Gefitinib (GFT) was a tyrosine kinase inhibitor (TKI), also known as a cancer growth inhibitor. The aim of this research work was to develop in Nanoemulsion (NE) loaded with Gefitinib (GFT), for anticancer EGFR inhibitor activity. Nanoemulsion (NE) were fabricated by Vortexing technique. Oleic acid was used as oil phase. Tween 80 was employed as surfactant and Polyethylene glycol 400 was employed as co-surfactant phase. Optimised Nanoemulsion (NE) (M 12) had droplet size 55.25 ± 0.45 nm and drug content of gefitinib (GFT) was 99.88 ± 0.12 % respectively.