Aim and objectives: The present study was done for the purpose of evaluating synergistic anti-ulcer activity of Aeglemarmelos and Ocimum sanctum in ulcer induced wistar rats. Materials and methods: Healthy 30 wistar rats of either sex were taken for this study. Rats were grouped randomly in study groups and ethanol extracts of Aeglemarmelos and Ocimum sanctum were given as per the study protocol. Ulcers were induced by forced swim methods. Results were calculated with the control group. Results: The ethanolic extracts of Aeglemarmelos and Ocimum sanctum showed significant anti-ulcer activity in forced swimming method. Conclusion: In the present study, combination of Aeglemarmelos and Ocimum sanctum at the dose of 300 mg/kg (150 gmeach of AM and OS) showed a significant anti-ulcer activity as compare to dose given of Aeglemarmelos (300mg/kg) and Ocimum sanctum (300mg/kg) individually. Ulcer index reduced as compared to control group and its results were similar to standard drug Omeprazole (20mg/kg), as evidenced by the decrease in gastric lesions.

With discovery of new disease and disorder it is necessary to invent new and novel drug delivery system. So that the drug reaches its target site and maximum absorption of drug occurs. With newer drug delivery system many advantages like decrease in drug dose, drug loss, toxicity, side effects and time require for onset on action have been observed. The vesicular delivery system consist of liposomes, pharmacosomes, ethosomes, transferosomes, niosomes and many more. Pharmacosomes are colloidal dispersions of drug covalently bounded to lipid. They may be present as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure of drug-lipid complex. Pharmacosomes are ampiphillic in nature and hence can encorporate both hydrophilic and lipophillic drugs. They are generally used for NSAID, cardiovascular, protein, neoplastic drug encorporation. Encapsulation of drug in vesicular system increases time span of drug in systemic circulation and hence its bioavailability.

Nanomedicines should be properly screened before they can be hailed as the pharmacological boon of the future. The present study encapsulates the acute and subacute toxicological aspects of the ZnO-Siziyumjambolanum (SJ-ZnO) nanocomposites synthesized. The individual components of the formulation, viz ZnO in surface modified nano form and at low dose, and Siziyumjambolanum are both biocompatible materials. For toxicity evaluation of the nanocomposite, Biochemical, Hematological and Histopathological analysis were conducted along with Behavioural assays to ascertain any behavioural side effects. For acute toxicity studies according to OCED (Organization for Economic Cooperation Development) guidelines Female Wistar rats (6-7 weeks) were used and were given single intraperitoneal dose of 2000 and 5000mg/kg body weight and were observed for mortality and other side effects for 14 days and for subacute toxicity studies, swiss albino mice of either sex (8-10weeks) were randomly divided into 4 groups (n=6) where in group I as vehicle treated control. Group II and Group III and Group IV received 150, 300, 500 mg/kg body weight of SJ-ZnO for a period of 28 days. The animals were sacrificed on the 29th day to evaluate the toxicological implications of the nanocomposite. Low and middle dose showed little or no change in the biochemical and haematological parameters. Very slight changes were observed in the tissue level from histopathological data analysis of the high dose. It is thus concluded from this study that the nanocomposite synthesized is safe and nontoxic and can be used as a therapeutic nanomedicine.

Ficus religiosa is a sizable broad-leaf evergreen woody plant have always been the important form of the medicinal drug in the south Asian country including Bangladesh, India Pakistan, Nepal, Bhutan, Sri Lanka in care of a variety of diseases and disorders such as insomnia, pain, inflammation, jaundice, and fever. Ficus religiosa has therapeutic properties due to the presence of the different complex chemical substance of different composition, which is found as secondary plant metabolites in one or many parts of these plants. The present aim evaluated the sedative and anxiolytic potentials of the ethanol extract of leaves of Ficus religiosa in various activity models in mice and update information on its phytochemistry and pharmacological activities. The sedative action of EEFR was investigated by using open field, hole cross, rotarod, and thiopental sodium- (TS-) induced sleeping time finding tests, where the overhead plus maze (EPM) and light-dark box (LDB) attention tests were employed to support the anxiolytic potentials in mice at the doses of 100, 150 and 200mg/kg. The issue illustrated that EEFR significantly inhibited the exploratory activity of the animals both in hole cross and in open field tests in a dose-dependent mode. It also reduced motor coordination and modified TS-mediated hypnosis in mice. On The other hand, EEFR showed anxiolytic potential by increasing the number and time of entries in the open arm of EPM, which is further strengthened by the increase in gross time spent in the light part of LDB. Therefore, this study suggests the sedative and anxiolytic properties of the leaves of Ficus religiosa and help the traditional utilization of this plant in the treatment of different psychiatric disorders including insomnia.

In recent years a lot of folks throughout world square measure turning to use medicative plant merchandise in care system. Worldwide want of different medication has resulted in growth of natural product markets and interest in ancient systems of drugs. Proper integration of contemporary scientific techniques and content is very important. The identification of purely active moiety is an important requirement for Quality control and dose determination of plant related dugs. Standardization of seasoning medication suggests that confirmation of its identity, Quality and purity. The present summary covers the standardization parameters with their standards worth of the some seasoning medication. There is a growing focus on the importance of medicinal plants in the traditional health care system and #40; viz. Ayurveda, Unani, Homoeopathy, Yoga and #41; in solving health care problems. Systematic approach and well-designed methodologies for the standardization of seasoning raw materials and seasoning formulations square measure developed.