The objective of the present investigation was to design and develop gastroretentive drug delivery system of Metformin Hydrochloride. Floating tablets of Metformin Hydrochloride was developed using gas forming agents, like sodium bicarbonate, citric acid and polymers like Acacia gum and Xanthan gum. Tablets were prepared by wet granulation method. The prepared tablets were evaluated in terms of their pre-compression parameters, physical characteristics, estimate of drug content, total buoyancy time, buoyancy lag time and in vitrodrug release amount. The results of the in vitro drug release studies showed that formulation one (FM-1) and formulation three (FM-3) had better control over release of drug. Formulation one resulted in sustained drug release of 76.3% over a period of 18hrs and formulation three resulted in sustained drug release of 77.27% over a period of 13hrs. It was concluded that these formulation could be given one dose per day. Formulation two (FM-2) might not have had good results asother two formulation but it produced sustained release of 96.79% over a period of 12hrs. And it was conclude that it can be given two doses per day. The drug release of all formulations improves uniform drug availability and helps increase adherence.

The major problem in formulation of oral films of telmisartan is that it belongs to BCS Class II moiety. Pharmacologically telmisartan is an angiotensin II receptor antagonist which has high affinity towards the type I (AT1) angiotensin receptor. Telmisartan is absorbed over 4 hours, and its bioavailability is only 25%. Hence there is a need to increase the oral bioavailability of telmisartan by formulating it in to solid dispersions and incorporating the same in to the formulation of fast dissolving films which gives fast onset of action. Six formulations (FT1-FT6) of telmisartan films were prepared and evaluated for their physical characteristics such as thickness, tensile strength, weight variation, folding endurance, drug content uniformity and surface pH and gave satisfactory results. The compatibility of the drug in the formulation was confirmed by FTIR studies. The formulations were subjected to disintegration, in vitro drug release studies and formulation FT5 was found to be best formulation which contain HPMC+ Maltodextrin as film forming polymers along with telmisartan solid dispersion with polyvinyl pyrollidone K30 at weight ratio of 1:4 showed excellent film forming characteristics such as disintegration time of 57 sec and percentage drug release 90.34% within 10 minutes.

A simple, specific, sensitive, precise stability-indicating high-performance liquid chromatography method for determination of Armodafinil was developed and validated. A Agilent TC C-18 column (250 x 4.6 mm, 5 μ) in isocratic mode, with mobile phase consisting of a mixture of solution Methanol: water (60:40) was used. The quantitation performed at flow rate of 1.0 mL/min at 225 nm and run time was 10 min. The analytical method was validated as per ICH guideline for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, robustness and stability and method can be extended to the analysis of Armodafinil in tablet formulation. The relative standard deviation values for precision was less than 2%, and % recovery was greater than 98% for Armodafinil. The drug undergoes acidic, alkaline, oxidative, photo and thermal degradations.

Liposomes are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of a lipid moiety and are well known to alter the bio distribution of entrapped substances by protecting the enclosed materials. They are widely used as vehicles or carriers to target the specific molecule to a specific organ especially in condition of bacterial infections. A development of system which controls the release and enhances the bioavailability of Mupirocin, an anti-bacterial agent is in demand. This study aimed at developing and optimising liposomal formulation of Mupirocin, a broad spectrum antibiotic of maximum therapeutic efficacy with minimal side effects by lipid film hydration technique using various ratios of soya lecithin and cholesterol. Upon pre-formulation studies and optimization, the various formulations (of varying proportions) were prepared and subjected for various physico chemical evaluation studies i.e., morphology, particle size, drug entrapment efficiency, in-vitro drug release, release kinetics and stability studies. Among five formulations (F1- F5) F4 formulation emerged as the most satisfactory formulation in all the evaluation parameters. The liposomes were found to be stable during their stability studies when stored at different temperatures. Hence it can be concluded that Mupirocin can also be loaded in liposomal carriers which found to be effective, stable and can be proceeded for further future studies.

Tablets are the solid dosage forms which are conventional over all pharmaceutical dosage forms. They are easy to prepare than any other dosage forms but during their manufacturing many problems will arise which will cause discarding of the entire batch and also post compression studies also very important to release the dosage forms in to the market. In this article we mentioned what are the problems (Picking, Sticking, mottling etc…) will arise during the tablet manufacturing and their remedies and also what are the Pre and post compression properties (Hardness, Thickness and Weight variation etc….) and their limits to release the dosage form in to the market.