Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipids that is caused by the deficiency of α-galactosidase A that affects males and shows disease expression in heterozygotes, is associated with dysfunction of many cell types and includes a systemic vasculopathy. As a result of the aberrant buildup of glycosphingolipids, there are a number of clinical symptoms, significant morbidity and mortality. Males who are hemizygous for the disease yet have no remaining -galactosidase. The disease's hallmark neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular signs may all be displayed by an individual, whereas heterozygous females may only experience mild to moderate symptoms. There is an enzyme replacement therapy for Fabry disease, but it is an expensive intravenous medication. Small molecule chaperone treatment and other alternative therapeutic modalities are actively being investigated. Other small molecule compounds, such as non-inhibitory chaperones, enzyme activators, molecules that decrease GLA substrate and molecules that activate GLA, can be found using high throughput screening (HTS) methods.

Powdered leaves of Moringa oleifera are useful in reducing stunting. Based on nutrigenomic and biological research, adding powdered Moringa oleifera leaves to supplemental foods may be beneficial to health. Molecular qualities that are anti-inflammatory, antioxidant, and anemia-preventing. Therefore, more study in these areas will be needed in the future. The moringa plant provides all of the essential elements that individuals need. They contain not only the essential nutrients but also some that aren't. Medical facilities, especially those in rural regions where malnutrition is common, should emphasize raising awareness of the nutritional and therapeutic benefits of moringa. One strategy is to brand Moringa as the "Family Tree" in order to encourage its planting in family compounds. "The purpose of this narrative review was to address undernutrition as a type of malnutrition in children, the strategies implemented in South Africa to address childhood malnutrition and its difficulties, complementary feeding practices in South Africa, particularly in KZN and the potential use of MOLP as a fortifier to increase the nutritional content of home-prepared complementary foods".

Pomegranate is worthy and salutary source of biologically active compound with healthful Properties. It reduces body consumption and body weight. Pomegranate is rich in anticancer, Antioxidants, anti-inflammatory and antimicrobial properties. It is also effective in digestive health and cardiac health. Pomegranate is rich in fibers, proteins, vitamins and minerals. It also maintain Hormonal imbalance it is used in the treatment of hair loss and also beneficial in the treatment of Menopause.

The objective of the present research work is to develop a formulation of carvedilol chewable tablets. The carvedilol belongs to the class of beta-adrenergic blockers which is used in the treatment of congestive heart failure, chest pain and hypertension. These marketed tablets are taken by swallowing. In order to reduce this problem chewable tablets are more efficient. The chewable tablets are prepared by using sweetening agent is aspartame to mask the bitter taste of the drug. Carvedilol chewable tablets are prepared by wet granulation method. Chewable tablets were prepared and evaluated. The pre-formulation studies of FT-IR revealed that there was no significant interaction observed between the drug and excipients. Formulated chewable tablets were characterized for appearance, weight variation, hardness, friability, drug content, in-vitro drug release studies. Formulation F8 containing 30mg of Sodium starch glycolate released 99.38% drug at the end of 6^th min better than other formulations. Formulation F8 could be considered as best formulation based on drug release profile, physical texture and other properties. Carvedilol chewable tablets could be served as promising drug delivery dosage form forcardiac patients with improved palatability and patients’ acceptance due to pleasant taste of the formulation.

For many years, natural materials have been used as a source of treatments and drug leads. Diverse methodologies inspired by natural products are used in the diversity-oriented synthesis of new small molecule libraries. A increasing body of evidence supports the efficacy of these strategies for identifying novel physiologically active chemicals. Moringa oleifera, a valuable medical plant, is one of the most commonly farmed species in the Moringaceae family. The plant's many parts have been used to create human medications. The literature review revealed extremely clear insights into this plant's historic use as an antispasmodic, stimulant, expectorant and so on. Bark has emmenogogue and abortifacient properties, as well as antibacterial and antifungal properties. Flowers can be diuretic, stimulant, cholagogue, or tonic. Antiviral, anti-inflammatory, and analgesic activities are found in root bark. Among the pharmacologically documented activity are antimicrobial, anti-inflammatory, oxidative, anticancer, antifertility, hepatoprotective, cardiovascular, antiulcer, analgesic, wound healing, anticonvulsant, antiallergic and anthelmintic effects.