The aim of present research is at phytochemical and the in-vitro comparative study of the anthelmintic activity of aqueous and ethanolic extracts of seeds of Trachyspermum roxburghianunm and Antheum graveolens using Indian adult earthworms (Pheretima Posthuma) at 2 different concentrations (10 and 20mg/ml) in two different vol. 10ml and 15ml respectively. The study involved the observation of the time of paralysis and the time of death of the worms. At the conc. of 20mg/ml in both vol. i.e. ten ml and fifteen ml the Ethanolic extracts showed more potent activities as compared to the standard drug Albendazole at two different concentrations (10 and 20mg/ml) volume taken 15ml. Ethanolic extract gives more potent result than aqueous extract when compare to standard. But aqueous extract has also shows anthelmintic activity. In conclusion, aqueous and ethanolic extracts of seeds of Trachyspermum roxburghianun and Antheum graveolens as an anthelmintic have been confirmed and further studies is suggested to discover the active principles responsible for the activity.

In the present work, the effort was focused on trying the use of Nano materials for drug delivery and Carbon Nano material (CNM) was chosen, because surface of CNMs can be functionally modified, also it has potential biocompatibility. Carbon Nano Tube was functionalized by acid treatment. Surface morphology of the Carbon Nano material after acid treatment was assessed by SEM and TEM characterization. FTIR of functionalized CNT showed the introduction of –COOH and –OH groups which was thought to be suitable for attachment of drug molecules by non-covalent bonding.

Difficulties of swallowing and first-pass metabolism are of the major limitations of oral medicaments resulting in patient non-compliance and poor oral bioavailability. Many of the drawbacks in that can be avoided by the administration of another dosage forms e.g. Mouth Dissolving Tablets (MDTs) that dissolve upon contact with saliva and consequently allowing systemic drug absorption via buccal mucosa. This study aimed to prepare MDTs prepared by Clopidogrel containing disintegrants. MDTs were prepared using different other excipients where powdered blends were evaluated to investigate their flow properties followed by physical evaluation of the directly compressed tablets.

Diabetic osteoporosis (DOP) is a prevalent metabolic bone disease marked by low bone mineral density (BMD) and microstructure degradation. It has been reported that geraniin is good for osteoporosis; however, it has not been reported whether geraniin protects against diabetes-induced osteoporosis. In this study, a rat model of diabetic osteoporosis was established by streptozotocin injection, the bone protective effects and potential mechanism of geraniin on diabetes-induced boneloss was observed. Wistar albino rats were divided into three groups; control group (vehicle treatment), Streptazocin (diabetic) group and Geraniin group (diabetic rats treated with geraniin), 6 rats in each group. After 8 weeks of geraniin treatment, the bone mineral density (BMD) was measured. The results demonstrated that consuming 40mg/kg of geraniin reduced blood glucose and improved BMD in diabetic rats. All of the evidence suggests that taking geraniin orally can help prevent diabetic osteoporosis; the impact is mostly due to its capacity to raise BMD and lower blood glucose.

The medicinal mushroom Ganoderma lucidum is famous due of its health-promoting qualities. The benefits of Ganoderma lucidum extract on cancer, hypertension, hypercholesterolemia and hepatitis have been documented by several researches. β-Glucans are a kind of medicine that belongs to the class of biological response modifiers. They have a wide range of biological functions that help people stay healthy. Dermatology, particularly wound care, is a specialty. The goal of this study was to see how β-Glucans affected the healing effectiveness of an aqueous lyophilized extract of Ganoderma lucidum from on a cutaneous excision lesion in rats. With a reference povidone-iodine ointment, the healing effectiveness was compared. The Ganoderma lucidum +β-Glucans extract significantly increased wound contraction, indicating improved healing activity. The findings show that β-Glucans greatly improved Ganoderma lucidum's wound-healing ability.

A new, simple, specific, rapid, accurate, and precise reverse phase HPLC method was developed for Etravirine tablets. They were chromatographic on a reverse phase column-(Symmetry c8, 150 x 4.6mm, 5µ), in a mobile phase consisting of mix buffer solution and methanol in the ratio (35.65).

Baobab (Adansonia digitata) is a multi-purpose tree with tender root, tubers, twigs, fruit, seeds, leaves and flowers which are edible. Owing to the nutritional and medicinal benefits of baobab tree parts, it has been used for various purposes for the past two centuries in Africa, and some parts of Asia. This has in recent times led to some statutory bodies approving its use in certain food products. Adansonia digitata has popular ethnomedicinal application in the treatment of malaria in sub-Saharan Africa. Medicinal plants have been found to contain phytoconstituents of relevance in phytomedicine. Plants have provided active ingredients of medicines for years and are still sources of lead compounds in the development of new therapeutics A. digitata (baobab tree in both English and French), are used in the treatment of malaria, fever, among other ailment. The mechanism of anti plasmodial action of this extract has not been elucidated, however, anti plasmodial effects of natural plant products have been attributed to some of their active phytochemical components. A. digitata, having reported to be a rich source of antioxidant phytochemiclas different mechanism might be involved.

Achyranthes Aspera Linn (Amaranthaceae) is a plant that is widely available in India. Tamil Nadu residents have traditionally used this herb to treat cuts. Wound healing properties have been reported for aqueous extracts of Achyranthes aspera (Achyranthes aspera) leaves. β-Glucansare a type of medication that comes from a range of sources, including yeast, grain and fungus. They belong to the biological response modifiers class of medications. They have a wide range of biological activities that boost human immunity. Dermatology, particularly wound treatment, is one promising application for β -Glucans. The goal of this study is to determine the effect of biological response modifier β -Glucans in improving Achyranthes aspera wound healing. Two wound models, an excision wound model and an incision wound model, were used to study wound healing activity. The extracts were further tested for free radical scavenging activity using two methods: DPPH radical scavenging activity and superoxide scavenging activity. In both wound types studied, the extracts and their combination showed a substantial response. In the two models investigated, the plant also had a strong antioxidant impact, reducing the generation of free radicals. These findings point to the possibility of using this combination to treat wounds.

Superporous hydrogels (SPHs) were developed to retain the drug within the gastric medium. These systems swell very rapidly within the stomach and maintain their integrity for extended time even within the acidic environment of stomach, while releasing the pharmaceutical active ingredient. The present work focuses on concept of development of superporous hydrogel tablets of Labetalol Hcl, their comparativeness to the marketed delayed release dosage forms. The aim of this study was to prepare Gastroretentive dosage form based on SPH using Labetalol Hcl, a antihypertensive as a model drug for swelling and prolonged drug release characteristics in acidic pH. There are three different polymers in SPHs, such as, sodium alginate, pectin, chitosan and acrylic acid were used with different concentrations by crosslinking technique using formaldehyde as cross linking agent to get the desired sustained release profile over a period of 8-12 hrs. The evaluation studies for SPH were measured by apparent density, mechanical strength, porosity, swelling studies, scanning microscopy (SEM) and FT-IR. All prepared formulations were evaluated for stability, kinetic drug release and in-vitro drug release profile, drug content and conclusions were that the proposed gastroretentive drug delivery system based on SPHs is promising for stomach specific delivery of Labetalol hydrochloride.

For the better treatment of a disease, buccal delivery is mostly priffered route from the ancient decade. This is the novel concept in buccal drug delivery is fast dissolving tablets (FDTs) are mostly accepted in the current situation. Mouth dissolving tablets are solid dosage forms which, when placed in the mouth, disintegrate, dissolve and release active agent within a few minutes without the need for water. It has more significance to geriatric, Pediatric, bedridden patients because they have a problem in swallowing and the patient with dysphasia. It is more useful for the traveler and busy patients who don’t have easy access to water. Mouth dissolving tablets are prepared by various technologies with the aid of superdisintegrants. Mouth dissolving tablets are more trustworthy than predictable dosage forms like capsules, tablets because of better patient compliance. The advancement in this field allows the development of an economic and better way of disease management with avoidance of several problems related to the other delivery systems.