The present research was aimed towards developing an oral dosage form having Lisinopril sustained release. Lisinopril is the BCS Class III drug under the Biopharmaceutics Classification System. There are various polymers used in trial-and-error method, among these HPMC and Eudragit and were taken in the ratio 2:5, had successfully retarded the release of Lisinopril for 24hrs in a rate-controlled manner. Hence the present work suggests HPMC as suitable rate retarding polymer for control release formulation of Lisinopril and the study recommends in vivo evaluation of the best optimized formula. As per the proto type evaluation results it was concluded that wet granulation is the best possible method of granulation for the present work. Pre-formulation studies were conducted to check the drug polymer and excipients compatibility and the results had confirmed compatibility among them. Granules were evaluated for tests like bulk density, tap density, compressibility index before compression.

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit, commonly characterized by the formation of comedowns, papules, pustules and increased sebum secretion. It affects a large proportion of the adolescent and adult population and may lead to physical as well as psychological distress. Although several synthetic treatments are available, their use is often associated with adverse effects such as skin irritation, dryness and microbial resistance. This has led to a growing interest in herbal therapies, which are generally considered safer, cost-effective and more acceptable to patients. The present study was undertaken to formulate and evaluate a herbal anti-acne gel incorporating ethanolic extracts of Azadirachta indica and Allium sativum. Both plants are well known for their antimicrobial, anti-inflammatory and antioxidant properties. The extracts were prepared using ethanol as a solvent and incorporated into a suitable gel base to obtain a stable topical formulation. The prepared gel was evaluated for various physicochemical parameters including appearance, homogeneity, pH, spread-ability and extrudability to ensure its suitability for topical application. Furthermore, the anti-acne activity of the formulation was assessed against Staphylococcus aureus using standard microbiological techniques. The results demonstrated that the formulated gel exhibited satisfactory physical characteristics and was compatible with skin pH. The combination of Neem and Garlic extracts showed significant antimicrobial activity, with enhanced effectiveness observed when used together, indicating a synergistic effect. In conclusion, the developed herbal anti-acne gel possesses promising therapeutic potential and could serve as a safer alternative to conventional synthetic treatments for acne vulgaris. Further clinical studies are recommended to validate its efficacy and safety in human subjects.

Improving patient adherence to treatments for alopecia and scalp disorders can be significantly supported by the appropriate use of hair cosmetic products. Among these, hair wax plays an important role not only in styling but also in offering a degree of protection to the hair shaft. Hair wax is commonly applied to shape and hold hairstyles, while also forming a thin coating over the hair that may reduce environmental damage and moisture loss. When selected and used correctly, it can complement therapeutic regimens by enhancing the cosmetic appearance of hair, thereby improving patient confidence and willingness to continue treatment. For dermatologists, a comprehensive understanding of hair care products is essential in clinical practice. Variations in hair type, texture and ethnic background influence how products interact with the scalp and hair fibers. By recognizing these differences, clinicians can recommend suitable products, guide proper usage and minimize the risk of adverse effects such as scalp irritation, buildup, or follicular blockage. This personalized approach enhances treatment outcomes and ensures better management of hair and scalp conditions. Historically, natural and plant-derived ingredients have been widely incorporated into hair care formulations. These substances are often preferred due to their favorable safety profile and lower likelihood of causing harmful side effects. A growing body of scientific evidence supports the use of botanical extracts for promoting hair growth, strengthening hair fibers and protecting against external stressors. Ingredients such as herbal oils, plant waxes and extracts rich in antioxidants and nutrients contribute to maintaining scalp health and improving hair quality. Choosing the right hair wax is therefore an important aspect of both personal grooming and supportive hair care. An ideal product should provide adequate hold without making the hair excessively stiff or greasy, should be easy to wash out and should contain ingredients that do not irritate the scalp. Attention should also be given to formulation type-whether water-based or oil-based-as this affects texture, durability and ease of removal. By understanding these factors, individuals can select a product that aligns with their styling needs while also supporting overall hair health.