Rivastigmine orally dispersible tablets were successfully manufactured according to the experimental procedure. Literature research and the trial and error method the quality of orally disintegrating tablets were selected. The tablets were found to have suitable physicochemical properties as well as desirable disintegration time and hardness. The Drug and polymer compatibility studies were examined DSC. Stability aspects of ODT formulations were evaluated using stability studies according to ICH guidelines and data complied with regulatory requirements. Orodispersible rivastigmine tablets have been successfully developed for Alzheimer's disease patients by direct compression technology. This technique is recommended by the US food and drug administration over similar solvent granulation techniques with the addition of superdisintegrants. This compounding process is faster and more economical than other techniques. His developed ODT formulation was compared with commercial products. The results were in good agreement with the disintegration time, wetting time and in vitro drug release profile. The developed ODT overcomes the problems of patient compliance, efficacy, side effects, weight gain and high cost associated with the use of conventional dosage forms in the treatment of Alzheimer's disease.

Background: The antioxidant activity of methanolic extract of papaya leaf lies in early leaf extract of Carica papaya. Aim:The study was designed to formulate herbal foot cream of ethanolic extract of Carica papaya and evaluate its physicochemical properties. Materials and methods: Three formulations were prepared with 1%, 1.5%, 2% of alcoholic extract of Carica papaya. All the formulated creams were evaluated for appearance, pH, viscosity, Spreadability, irritancy, moisture absorption study, antimicrobial and stability study. Results: The pH of formulations was found to be suitable for topical preparation. The prepared formulation showed good spreadability and consistency and didn’t show any irritation to the skin. Conclusion: Out of three formulations F3 containing 2% Carica papaya has showed better properties. The optimized formulation was subjected to antimicrobial study and stability study. The cream showed good antimicrobial activity and was found to be stable.

Udara Noi Nivarana Thiravagam is a herbo mineral formulation taken from Anuboga vaidya Navaneetham which has been indicated for its anti microbial properties. All the ingredients in the drug were properly collected, preserved and authenticated by experts. The Ingredients are purified properly as per the traditional Siddha Literatures. The aim of the present study was to validate the anti microbial property of Udara Noi Nivarana Thiravagam. Preface: The present study examined the in-vitro screening of antimicrobial activity of siddha drug Udara Noi Nivarana Thiravagam in albino rats. Methology: The antimicrobial activity of Udara Noi Nivarana Thiravagam were tested for antimicrobial activity through Kirby-Bauer method (Agar diffusion testing). The microorganisms used in the present study include Staphylococcus aureus, E.coli, klebsiella, pseudomonas aurigenosa. Outcome: It was observed that antimicrobial studies of UNT showed that it is sensitive against E-coli, Klebsiella penumoniae and Pseudomonas aeruginosa.

Rose is a sacred ancient plant with a long history of usage in Iranian traditional medicine and is one of the most important plants in the Rosaceae family. Although rose is used in folklore as rose water or dried rose petals, the majority of rose's applications are in the production of rose water and rose essential oil for use in religious ceremonies, cooking of some dishes and high grade perfumes. Rose essential oil is a valuable industrial commodity with numerous applications. The production of rose essential oil is quite low [0.3e0.4ml/kg]. The chemical makeup of rose essential oil may be affected by ecological, geographical and environmental circumstances, soil composition, harvesting and storage conditions and distillation procedures. The best rose essential oil contains a high concentration of monoterpenes. As a result, developing techniques to increase oil yield while decreasing oil production costs is a significant challenge for the future.

The main purpose of this study is to describe the formulation and evaluation of chitosan nanoparticles loaded with montelukast sodium. The prepared nanoparticles exhibited smaller particle size, acceptable polydispersity index, higher positive zeta potential, better trapping efficiency and loading capacity, and relatively improved release and permeation profiles of the prepared nanoparticles. Formulated montelukast sodium chitosan nanoparticles can exhibit higher drug concentration in the mucosa without animal mortality, hematologic changes, body weight fluctuations, and histopathological changes. Therefore, it was concluded that chitosan nanoparticles loaded with Montelukast sodium can facilitate direct delivery from the nose to the brain, thereby increasing drug concentration in the brain. The research could lead to the development of nanoparticle drug delivery systems that could help treat asthma and seasonal allergies such as sneezing, itching and rhinitis.