A reverse phase high performance liquid chromatographic method was developed for the determination of Lumacaftor and Ivacaftor in bulk and Pharmaceutical dosage form. The separation was effected on a C18 column (250mm x 4.6mm; 5μm) using a mobile phase mixture 50 volumes of Acetonitrile and 50 volumes of phosphate buffer in a ratio of 80: 20v/v with a flow rate of 1ml/min. The detection was made at 259nm. Calibration curve was linear over the concentration range of 50-250μg/ml of Lumacaftor and 31.25-156.25µg/ml of Ivacaftor. The proposed method is validated as per the ICH guidelines. The method is accurate, precise, specific and rapid and found to be suitable for the quantitative analysis of the drug and Pharmaceutical dosage forms.

Ground water is one of the substantial fresh water resources accessible for human requirement. Early people documented the significance of water from a quantity view point. However appraisal of the quality of ground water is required for improving its potability. In the present work appraised the water quality of Jagalur taluk and its surrounding areas, which is located 51km away from the Davangere city at 14.53oN 76.35oE of Karnataka, India. Water quality is analyzed for about 10 physico-chemical variables of 25 water samples collected from diffrent locations of 25 villages from Jagalur Taluk. The ground water samples are collected physically from the bore-wells which were nearly equal scattered all over 25 villages of Jagalur Taluk. The samples were analyzed The EC and TDS were also measured in the spot at the time of sample collected using water analysis kit (Elico-make) and fixation of dissolved oxygen was done immediately after the collection in the field by Winkler’s method. Then the ground water samples were transported to the laboratory for the analysis of various physio-chemical variables. The combined effect of all there variables was expressed in terms of WATER QUALITY INDEX Jagalur taluk map has been collected and analyzed. The data base obtained from water quality testing is used as characteristics to compare the quality for drinking purposes and the spatial scattering of various water quality variables. The water present in the villages like Borapura, Rangaianadurga, Gowripura and Gopalpura was found to be unfit for drinking. The conclusion of the current research may be abundent for proper decision making for policy of the treatment facilities by the establishment.

Coronavirus are goes under an expansive group of infection that can cause respiratory sicknesses, for example, the normal chilly, as per the Centres for Disease Control and Prevention (CDC). They are normal in various types of creatures, including camels and bats. Surprisingly, these crown infections can develop and taint people and afterward spread between people. Ongoing instances of this incorporate SARS-COV and MERS-COV. 2019 Novel Corona infection (2019-nCoV) is an infection recognized as the reason for a flare-up of respiratory ailment initially identified in Wuhan, China. This infection causes respiratory diseases in people, which are hourly gentle however are possibly deadly. Now and again, the infections can cause lower-respiratory tract ailments, for example, pneumonia and bronchitis. In human crown infections are right now characterized into seven sorts that are HCoV-229E, HCoV-OC43, HCoV-NL63, SARS-COV, HKU1, MERS-COV and 2019-nCoV. These two kinds of crown infection (MERS-COV and SARS-COV) are progressively risky. The Novel crown infection (2019-nCoV) is newfound, or recently started, and is a placeholder name and furthermore known as Wuhan pneumonia or Wuhan crown infection. Some of crown infections like HCoV-229E, HCo-OC43, HCo-NL63 and HKU1 that are constantly course in the number of inhabitants in human and cause respiratory contaminations in human either may youngsters and grown-ups around the world. They are commonly transmitted among creatures and people through wheezing, hacking, contacting or shaking hands and reaching a surface or article. The side effects of crown infection are wheezing, hack, weakness, runny nose, sore throat, breathing trouble and exacerbated. In progressively serious cases SARS, kidney disappointment, pneumonia and even passing. Conclusion can be completed by social insurance supplier in research center test on respiratory examples and serum to recognize human crown infection. To counteraction of crown infection by covering mouth and nose when sniffling and hacking, maintain a strategic distance from unprotected contact with live creatures and furthermore washing hand with cleanser and water. For this infection no particular treatment like immunizations and antiviral medications however manifestations can be dealt with.

Objective: The Eleagnus Latifolia Wild are worldwide distributed plant which native mainly to subtropical regions of Asia, North America, southeastern Europe. Has different utilized in people medication as calming, muscle relaxant, antipyretic, pain relieving, astringent and antiulcer operator. Methods: Eleagnus Latifolia was gathered from B. Maduvangarai, Tamil Nadu, India. The leaves were gathered and extricate arranged from ethanol by hot nonstop permeation technique in soxhlet contraption for 24 hours. The ethanolic extract was collected and analyzed using Perkin -Elmer Gas Chromatography-Mass Spectroscopy for the identification of active biochemical constituents present in the leaves of Eleagnus Latifolia Willd. Results: GC-MS analysis of ethanolic extract Eleagnus Latifolia of leaves of showed 12 bioactive compounds, the highest compound was named .Alpha.-D-Mannofuranoside, Methyl and lowest was named Distearyl Sulfide. Conclusion: In the present study, we concluded that the phytochemical constituents of ethanolic extract of leaves of Eleagnus Latifolia by Gas Chromatography and Mass Spectrometry (GC-MS), to furnish the scientific information to evolve potential phytomedicine.

Medicinal plants are regular word which would everyone be able to mouth that is useful in treating numerous maladies which doesn't done by even allopathic medication. Among those the birth control at the same time increasing the fertility of human being are both become major problems in nowadays. This audit articles some short introduced refreshed data accumulated on logically demonstrated therapeutic plants utilized for against richness movement. This study provide information on name of the plants, family, parts used and therapeutic effects of medicinal plants have been reviewed for thorough research inclusive of Amaranthus, Acacia concinna, Adhatodavasica, Alangium, Barleriaprionitis, Buteamonosperma, Cassis fistula, Carica papaya, Celastruspaniculatus, Daucus Carota, Flagellariaindica, Franseriaartemisiodes, Hibiscus rosa-sinensis, Indigoferalinnaei, Laurusnobilis, Nigella sativa, Oleaeuropea, Papaver, Piper longum, Portulacaoleracea, Ricinuscommunis, Rutagraveolens, Salvia fruticosa, Taxusbaccata, Trigonellafoenumgraecum, Valeriana Montana, Vitexnegundo, Xanthium spinosum, Ziziphoratenuior, Zizyphus jujube, etc. This overview in reality demonstrates that it's time to make bigger upon experimental studies to source medicinal plants, plant extracts and their lively elements ought to be in addition investigated for their mechanisms. This review creates a strong foundation upon which to similarly examine the efficacy of plants which are both presently utilized by Female as traditional antifertility medicines, however also could be efficacious as an antifertility agent with extra research.