Inflammation is the complex biological response of vascular tissues to harmful stimuli including pathogens, irritants or damaged cells. Mainly NSAIDs are effective for the treatment of pain. The factor limits the use of the NSAIDs is the gastrointestinal toxicity. It is mainly the developments of potent anti-inflammatory drugs and from the natural products which are under considerations. The herbal products are rich source for discovery of new drugs because of its chemical diversity. Herbal products from medicinal plants are playing a major role to cure many diseases associated with the inflammation. The conventional drugs are available in the market to treat the inflammation which produces various side-effects. Due to these side-effects there is need for the search of newer drugs with less or no side-effects. The review analyses extracts and phytochemicals derived from the Indian herbal plants evaluated for the possible anti-inflammatory activity.

A novel, simple, sensitive and rapid Chromatographic (RP-HPLC) method has been developed for simultaneous estimation of NSAIDS (Serratiopeptidase and Diclofenac sodium) from pharmaceutical formulation. The present isocratic method was carried out on analytical column- WATERS XTERRA RP8 (4.6x150, 5 microns) with pH -3 adjusted mobile phase [Ortho Phosphoric acid buffer: methanol 70:30 (v/v)] at the flow rate 1.0 mL/min. The detection was carried out at wave length (λ max) 262 nm. The average retention time of diclofenac sodium was 3.763 min and Serratiopeptidase was 5.480min. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for the estimation of these drugs in combined dosage forms.

The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered, thus they must be detected and quantitated. For this analytical instrumentation and methods play an important role. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs. The review highlights analytical techniques such as chromatography, spectroscopy, electrophoresis and their corresponding methods that have been applied in the analysis of pharmaceuticals.

Nanotechnology is a fast emerging discipline not only in physics and chemistry but also in the field of biology. Nanoparticle synthesis and the study of their size and properties are of fundamental importance in the advancement of recent research in the field of medicinal search. The leaves of Artocarpushirsutus were used to synthesize silver nanoparticles. Silver nitrate is used as reducing agent as silver has distinctive properties such as good silver conductivity, catalytic and chemical stability. The aqueous silver ions when exposed to plant extracts were reduced in solution, there by leading to the formation of silver hydrosol. The time duration of change in color varies from plant to plant. The synthesis of SNPs had been confirmed by measuring the UV-Vis spectrum of the reaction media. The preliminary analysis of the extracts was performed to determine the presence or absence of the primary or secondary metabolites. The nanoparticles synthesis by green route was found toxic against bacterial species at a concentration of 100 micro liter Ag nanoparticles revealed higher antimicrobial activity against Stephylococcusaureas and E.coli.

Lornoxicam is a non-steroidal anti-inflammatory drug with analgesic properties and belongs to the class oxicams. It is extremely bitter in taste.The purpose of this research was to develop a bitter less oral disintegrating tablet of poorly soluble drug like lornoxicam. Taste masking was done by complexing with kyron T-104 in different ratios. Three super disintegrants like sodium starch glycolate, low substituted hydroxypropylcellulose and crospovidone were used. Prepared tablets were evaluated for different properties like drug content, hardness, friability, wetting time, water absorption ratio, disintegration time and Invitro dissolution study. The different formulations showed disintegration time between 5-35 sec. Drug releases showed between the ranges of 5-30 min. Among all the formulations, F9 showed 98.53% drug release within 30 min. Thus, F9 was considered best among the other formulations. The tablets showed enhanced dissolution hence better patient compliance.