The objective of this research was to formulate a cream for the treatment of cracked Heels using Hibiscus leaves extract and Aloe Vera as a key ingredient. The cream formulation, comprising Hibiscus leaves extract, Aloe vera juice, coconut oil and beeswax was prepared and evaluated for various parameters including physical evaluation, pH, spread-ability, stability, viscosity and washability. The used product is compatible with other ingredients present in the formulation.

Pyrazinamide remains an essential antitubercular agent; however, its clinical application is often limited by rapid metabolism and dose-related toxicity. In the present investigation, a polymer-based nanosuspension system was designed to improve oral delivery and sustain drug release. Pyrazinamide nanosuspensions were formulated using cellulose acetate and a non-ionic stabilizer through a solvent displacement method, followed by chitosan surface modification. The formulations were evaluated for physicochemical properties, in vitro release behavior, compatibility and stability. The optimized formulation demonstrated nanoscale particle size, high drug encapsulation and prolonged release over 24 h, indicating its potential for improved oral therapy.

The formulation and evaluation of Phenytoin Oro Dispersible Tablets (ODTs) using super disintegrants aim to improve the dissolution rate and bioavailability of the drug. Phenytoin, an anticonvulsant, is poorly soluble in water, making its oral absorption slow and variable. Oro dispersible tablets offer a practical alternative by rapidly disintegrating in the mouth, enhancing patient compliance and drug release. In this study, various super disintegrants such as cross-linked polyvinylpyrrolidone (Crosprovidone), sodium starch glycolate (SSG) and croscarmellose sodium (CCS) were incorporated into Phenytoin ODT formulations. The tablets were prepared by direct compression method and evaluated for various parameters including hardness, friability, weight variation, content uniformity, disintegration time and in vitro drug release. The inclusion of super disintegrants significantly improved the disintegration time, which is a key factor in the rapid onset of action. The formulation with the optimal concentration of cross-linked polyvinylpyrrolidone showed the best drug release profile, with a higher dissolution rate compared to other formulations. The stability of the tablets was also assessed and the formulations exhibited good physical and chemical stability over a specified period. The results indicate that Phenytoin Oro Dispersible Tablets formulated with super disintegrants are an effective dosage form for improving the dissolution and bioavailability of Phenytoin, offering potential benefits for patients who have difficulty swallowing conventional tablets. Further studies are needed to confirm the clinical efficacy and pharmacokinetic profile of these formulations.