Drug formulation and development depend greatly on the drug's solubility. The most crucial pre-formulation parameter is determining the drug's solubility. For parenteral preparations, the drug molecules must be sufficiently soluble. In line with this, permeability and solubility both affect the bioavailability of solid formulations like tablets and capsules. The purpose of this study was to use a UV-visible spectrophotometer to examine the drug's solubility in various pH media. In the pH range of 1.2 to 7.4, the drug's solubility was investigated. This study has found that the solubility of fenofibrate is depending on pH.

New, simple, precise method has been developed for the estimation of Lamivudine using FT-IR spectroscopy inbulk and tablet dosage form. The quantitative analysis of Lamivudine was carried out using a pressed pellet KBr method. The method involve the measurement of peak of carbonyl group at 1671cm^-1. Linearity was observed atthe range of 10-18mg. The regression coefficient for the calibration data was y =0.0733x + 0.0058 with correlation coefficient of 0.9982 for Lamivudine. The value of the standard deviation did not exceed 2%. The respective method was successfully applied for the estimation of Lamivudine. The developed method was foundto be precise and accurate and also simple, economical and time consuming other than available method. This technique does not require any organic solvent which is considered as the chief advantage.

The incorporation of particular polymers into lipid-based formulations, such as self-nano emulsifying drug delivery systems, can sustain drug supersaturation after vehicle dispersion and/or digestion. Precipitation due to supersaturation and intraluminal solubilization behaviour has a significant impact on bioavailability, particularly for weak basic drugs. As a result, bioavailability improves. By interactions with poorly water-soluble and weak base drugs, polymers can be used to limit precipitation. This review presents an overview of the different types of precipitation inhibitors, drug precipitation mechanisms, describes the mechanisms by which precipitation may be inhibited, evaluation of supersaturated drug delivery system where PPI’s are incorporated, role of polymer precipitation inhibitors and recent applications of snedds.

Background: The formulated hair tonic contains fenugreek seeds are rich in Vitamin A, K and C, ginger improves the blood circulation in the scalps and leads to hair growth and shine, Amla rich in Vitamin A, Vitamin C and it increases the antioxidants in your body. It purifies the blood and enhances hair natural color by preventing premature greying of hair. It has antifungal and antiviral properties, which prevent dandruff and other fungal infections and improve scalp health. Aloe Vera act as natural conditioner and reduces the amount of dandruff and Neem has antibacterial and antifungal properties that reduce the side effects of dandruff, dry scalp and scalp infection, rose water eliminates dandruff and reduces the level of oil from scalps, that are completely natural and will make your hair smoother, stronger, shiner and dandruff free. Aim: The aim of this study is to formulate and evaluate the anti-dandruff herbal hair tonic using the above ingredients with an emphasis on efficacy and safety. Methods: Seeds of fenugreek, Ginger extract, Aloe Vera extract, Neem or Amla powder and Rose water were used in the formulation and subjected to Physical properties and appearance pH determination, viscosity, homogeneity, anti-microbial activity and anti-fungal activity. Conclusion: The evaluation parameters were fulfilled and shown in acceptance range and can be further instigated for production and testing. Result: The prepared herbal tonic was found to be in the stipulated pH range, viscosity, no skin irritation and microbial growth.

The purpose of modern-day studies is to formulate natural toothpaste the use of herbs like clove and kalonji oil. This mixture has in no way been used earlier than in any studies. These extracts have antibacterial and anti inflammatory properties. Herbal toothpaste with herbal elements is extra suitable in public opinion than chemical primarily based totally artificial formulations with inside the contemporary oral dental care state of affairs because of their protection and efficacy in decreasing dental caries and stopping different disorders. Clove oil incorporates eugenol as an antibacterial. The organized toothpaste became evaluated for one of a kind parameters like pH=7.4, spread ability, moisture content, foamability, antimicrobial test  for our respective f3 formula become performed and region of inhibition became located to be 15mm with a view to expand a extra powerful and solid product. This studies proves that our natural primarily based totally toothpaste method with herbal components is as first-rate because it receives in phrases of performance.