A simple, rapid and sensitive difference spectrophotometric method was used for the determination of Nelfinavir mesylate in pharmaceutical dosage forms. The method is based on the induced spectral changes upon changing the pH of the medium that differ in their UV spectra. Difference spectrum, obtained by keeping Nelfinavir mesylate in 0.1N Hcl in reference cell and Nelfinavir mesylate in 0.1N NaOH in sample cell, showed two characteristic peaks at 214nm and 236nm with positive and negative absorbance respectively. Difference of absorbance between these two maxima was calculated to find out the amplitude, which was plotted against concentration. The calibration curve is linear over the concentration range of 10-60 μg/ml (r²= 0.996). The method was successfully applied to the commercial pharmaceutical drug without interference from common ingredient accompanying the drug. The result statistically compared with those obtained by the reference method. The proposed methods were successfully applied to the assay of Nelfinavir mesylate in pure and tablet dosage form. No interference was found from tablet excipients at the selected wavelengths and assay conditions. The data were compared with those obtained from the spectrophotometric method given in the literature and no difference was found statistically.

A simple, accurate, precise and sensitive Spectrophotometric method was developed for the estimation of Clopidogrel bisulphate in pure and tablet dosage forms. The estimation of Clopidogrel bisulphate was carried out at maximum absorbance of 220 nm. The method was found to be linear and obeys Beer’s law in the concentration range of 1-14 mcg / ml with a correlation coefficient 0.998. The developed method was validated as per ICH guidelines and was found to be accurate and precise. Thus the proposed method can be successfully applied for the estimation of Clopidogrel bisulphate in pure and tablet dosage forms.

This study was to evaluate the effect of Plantago major Lextract. onincreasingofcaspase-3 level on hypergastrinemicrat (Rattus norvegicus) model. By experimental study and post test only with control group design, 20 of rats was divided in to 4 groups. Group I as a negative control was given aquadest per oral.Group II was given Plantago major L.extract 50mg/200gbwrat/day per oral. Group III was given Plantago major L.extract100mg/200gbwrat/day per oral. Group IV was given Plantago major L.extract 200mg/200gbwrat/day per oral. Omeprazole and Ciprofibratehave been used to induce hypergastrinemia on rats as an animal model.Blood sample wascollected for measurement of gastrin and caspase 3 level after 2 month intervention.There were increasing of gastrin level of rats up to 3-4 times fold compared to normal level. Statistic analysis show that there were significantly difference of caspase-3 levelbetween groups (p= 0,041; 95%CI)  Dose 200mg/200gBW rat/day per oral of Plantago major Lextract are mosteffective to increase the caspase 3 level. This research can be concluded that administration of Plantago major Lextract. can increase caspase 3 level indicate  thatPlantago major Lextracthas proapoptotic effecton hypergastrinemiarat (Rattus norvegicus) model.

Famotidine has been the most widely used drug for the treatment of peptic ulcer for many decades. Famotidine, an anti-ulcer drug, Poor bioavailability (50%) and Famotidine is less soluble in intestinal pH. This study aim to formulate floating tablets of famotidine using an effervescent approach for gastroretentive drug delivery system. Floating tablets were prepared using direct compression techniques using polymers like HPMC K4M and HPMC K100M and Xanthan Gum for their gel-forming properties. The tablets were evaluated for in vitro buoyancy and dissolution studies. Tablets were evaluated for physical characteristic viz. hardness, floating capacity, thickness, swelling index, and weight variation. From the above results the HPMC polymer alone is unable to control release rate. It releases drug >100% within 6 to 8 hours. In combination with Xanthan gum it release >80% in 12 hours. The results indicate that gas generated gastroretentive floating tablets of famotidine containing HPMC K4M, HPMC K100M and Xanthan gum provide better options for controlled release action and improved bioavailability.

Oral drug delivery remains the most preferred route for administration of various therapeutic agents. Recent advances in technology prompted researchers and scientists to develop oral disintegrating tablets with improved patient convenience and compliance. Oral dispersible tablets are solid unit dosage form which dissolve or disintegrate rapidly in the mouth without water or chewing. Novel Oral dispersible tablet technologies address many patient and pharmaceutical needs such as enhanced life cycle management to convenient dosing particularly for pediatric, geriatric and psychiatric patients who have difficulty in swallowing (Dysphagia) conventional tablet and capsules. Technologies used for manufacturing of Oral dispersible tablets are either conventional technologies or patented technologies. This review depicts the various aspects of Oral dispersible tablet formulation; superdisintegrants and technologies developed for Oral dispersible tablets, along with various drugs explored, evaluation tests and marketed formulations in this field.