A simple, economical, precise and accurate method is described for the simultaneous determination of Duloxetine hydrochloride (DULO) and methylcobalamin (MCA) in combined capsule dosage form. The method was based on absorption correction method which involves direct estimation of MCA at 351 nm, as at this wavelength DULO has zero absorbance and shows no interference. For estimation of DULO, corrected absorbance was calculated at 289 nm due to the interference of MCA at this wavelength using distilled water as a solvent. The two drugs follow Beer-Lambert’s law over the concentration range of 10-50μg/mL in both the drugs. The concentrations of the drugs were determined by using absorbance correction method at both the wavelengths. The proposed methods can be successfully applied in routine work for the determination of DULO and MCA in combined dosage form. The method was validated statistically.

The objective of the present investigation was to design and develop sustained drug delivery system of tablets. Sustained release tablets of Carvedilol was developed using different polymers like HPMC K₄M, Xanthan gum and Eudragit S-100. Sustained tablets of Carvedilol were prepared by wet granulation method. The prepared tablets evaluated in terms of their precompression studies, postcompression parameters and in vitro study. The results of in vitro drug release studies showed that formulation (FCSRT-7) has better control over release of drug (95.78%) when compared to marketed product (90.36%) for 12hrs.

Four new 2-substituted-benzimidazole derivatives (ADMRY1-4) were synthesized by simple synthesis of 2-methylchloride benzimidazole (I) from o-phenylenediamine. It is a versatile synthetic intermediate because removal of hydrochloric acid when treated with substituted aniline. The equimolar concentration compound (I) (0.01mol) is treated with different substituted aniline (0.01mol) in presence of ethanol as medium and catalytic amount of hydrochloric acid, refluxed it for 1-2 hrs resulted in to compound (II) to build a linear 2- substituted benzimidazole derivatives by a simple route. The newly synthesized compounds were characterized by its melting point and I.R, ¹HNMR, MASS spectroscopic methods. Further the synthesized compounds were screened for antimicrobial activity. Few compounds have shown moderate to mild antimicrobial activity when compared to standard ampicilin.

Transdermal systems are ideally suited for diseases that demand chronic treatment. Hence an antidaibetic agent of both therapeutic and prophylatic usage has been subjected to transdermal investigation. Glibenclamde a first generation hypoglycemic agent faces problems like poor solubility with large individual variation and extensive metabolism. In this study, matrix type transdermal drug delivery system of glibenclamide, an antidiabetic drug were prepared by solvent casting method using different polymers like HPMC/PVP/CMC in varied ratios. Dibutylpthalate was used as plasticizer and dimethysulfoxide (DMSO) and propylene glycol was used as permeation enhancers. The prepared tranasdermal patches of glibenclamide were transparent, smooth, uniform and flexible. The cumulative amount of drug release in 6hrs from the four formulations was 74.6%, 98.8%, 97.0%, 84% respectively. On the basis of ex-vivo drug release, the skin permeation performance formulation F2 was found to be better than other formulations and it was selected as optimized formulation.

The Present work was for the Formulation of Etodolac, which is practically insoluble in water, and Paracetamol which is sparingly soluble in water, as a single dosage form was a challenging task. The two different approaches were followed, one involving Separate granulation of Etodolac and Paracetamol and then mixing of two granules before compression. The second approach involved combined granulation of Etodolac and Paracetamol. There was light binding done in approach 1 of both granules and in approach 2 there was medium binding. The surfactant was added in both the approaches to aid the dissolution of Etodolac from the combination tablet. Disintegrant was added both intragranularly and extragranularly which enabled good disintegration of the combination tablet. Both the approaches followed were able to give good Disintegration time, Hardness Friability and other parameters of the tablet. Dissolution and Initial Assay values of both Etodolac and Paracetamol were found according to specifications. The three-month stability study samples kept in PVC packs at 25ºC and 60% RH also passes the test for Assay, Dissolution and other physical parameters. So it can be concluded that Etodolac and Paracetamol tablets formulated using both the approaches are good. The combined granulation approach is less time consuming and cost effective.