The epilepsy is one of the most common neurological conditions that show a prevalence rate in 1–2% of the world population. Although a considerable number of antiepileptic drugs are available for the management / treatment of epilepsy there is still an urgent need for development of new drugs as alternatives. Allium Cepha [family: Liliaceae]has been used, as anti epileptic agent in traditional system of medicine in India. However, there are no reports about its scientific validation for the claimed activity.Hence, the present study was aimed to explore the possible antiepileptic activity of bulbs extract of Allium Cepha in experimental animal models. For assessing of antiepileptic activity Pentylenetetrazole (PTZ) and MaximalElectro Shock (MES) induced convulsive models were used. Diazepam was used as a standard reference for all models. In PTZ and MES induced convulsion models, high dose, medium dose and low dose of Allium Cepha extract showed significant anti-epileptic activity by delaying the onset of convulsions and by prolong the onset of clonus and tonic-extensor convulsion.Thus, the result recorded with above experimental models confirms that hydroalcoholic extract of Allium Cepha bulbs possesses antiepileptic activity.
G. Prasanna Ramakrishna*, G. Kiran, Tulasi uma rani, Syed Ayesha begum, Y. Anuradha, Chedella Swetha.